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Sweet 16 Best Bets: Top Picks and Expert Predictions for March Madness

Mar 23, 2025; Raleigh, NC, USA; Duke Blue Devils forward Cooper Flagg (2) dunks the ball during the first half against the Baylor Bears in the second round of the NCAA Tournament at Lenovo Center. Mandatory Credit: Bob Donnan-Imagn ImagesMar 23, 2025; Raleigh, NC, USA; Duke Blue Devils forward Cooper Flagg (2) dunks the ball during the first half against the Baylor Bears in the second round of the NCAA Tournament at Lenovo Center. Mandatory Credit: Bob Donnan-Imagn Images
As exciting as the quantity in the first two rounds of the NCAA Tournament can be, the Sweet 16 takes it to another level with quality. Gone are the teams that were happy just to make the Dance. As the competitive balance of the games steps up, so too has our “Best Bets” list.

The following are our best Sweet 16 bets for Thursday and Friday’s games.

Sweet 16 Best Bets: Thursday March 27th

BYU (+180) vs. Alabama (-5.5), o/u 174.5

Time: 7:09 p.m. ET
Date: Thursday, March 27
Coverage: CBS
Odds via BetMGM

With one of the most productive offenses in the game and one of the worst defenses, it’s been hard not to bet the over whenever Alabama plays (over is 19-15-1). I know what you’re thinking: 174.5 is such a high number for a college basketball game.

Alabama games have had a total of 174.4 or greater nine times this season; the over was 6-3 in those games.

BYU averages around 81 points per game this season (No. 25). While its defense does not rank as low as Alabama’s, it’s not impressive either (No. 155, 71.4 ppg allowed). Both teams love to shoot threes.

 

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