The Indianapolis Colts will look to continue to build on interim coach Jeff Saturday’s first two games when they take on the Pittsburgh Steelers on Monday Night Football. The Colts (4-6-1) have played well under Saturday, defeating Las Vegas, 25-20, before losing 17-16 to NFC East-leading Philadelphia last week. Indianapolis will also be out to snap a seven-game losing streak to the Steelers (3-7). Pittsburgh, meanwhile, has lost three of four and is just 1-4 on the road this year.
Kickoff from Lucas Oil Stadium in Indianapolis is set for 8:15 p.m. ET. Indianapolis is a two-point favorite in the latest Colts vs. Steelers odds from Caesars Sportsbook, while the over/under for total points scored is 39.5. Before locking in any Steelers vs. Colts picks or NFL bets, you have to check out the NFL predictions from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has broken down Colts vs. Steelers on MNF. You can head to SportsLine to see the picks. Here are the NFL lines and trends for Steelers vs. Colts:
- Colts vs. Steelers spread: Indianapolis -2
- Colts vs. Steelers over/under: 39.5 points
- Colts vs. Steelers money line: Steelers +118, Colts -140
- PIT: Steelers are 6-2 against the spread in their last eight games following an ATS loss
- IND: Colts are 7-3 ATS in their last 10 games following a straight-up loss
- Colts vs. Steelers: See picks at SportsLine
Featured Game | Indianapolis Colts vs. Pittsburgh Steelers
Why the Colts can cover
Wide receiver Parris Campbell is looking for his third game in a row with five or more catches and 65-plus receiving yards. He had five catches for 53 yards in the last meeting with the Steelers, a 28-24 loss at Pittsburgh on Dec. 27, 2020. For the season, Campbell has 44 receptions for 440 yards and three scores. He also has five big plays, including a long of 38 yards, and 23 first-down conversions.
Defensive end Yannick Ngakoue tied his season high with 1.5 sacks and had his first forced fumble of the season last week. He will be looking for his sixth game in a row with at least a half-sack. He has registered 21 tackles on the year, including 11 solo, with 6 1/2 sacks for 39 yards and four tackles for loss. In his eight-year career, Ngakoue has 62 sacks, 21 forced fumbles and three fumble recoveries. See which team to pick here.
Why the Steelers can cover
Wide receiver Diontae Johnson has five or more catches in 13 straight road games and five or more catches in 38 games since 2019, fifth-most in the NFL. He had eight catches for 74 yards and a receiving touchdown in the last meeting with the Colts. For the season, Johnson has 51 receptions for 456 yards (8.9 average) with three explosive plays of 20 yards or more. He has 97 yards after the catch with 22 first-down conversions.
Rookie wide receiver George Pickens led Pittsburgh with 83 receiving yards and had his second career receiving touchdown last week. Pickens will look for his third game in a row with a touchdown. He has 33 receptions for 453 yards (13.7 average) with 10 explosive plays of 20 yards or more this year, including a long of 36 yards. He has 73 yards after the catch with 22 first-down conversions. See which team to pick here.
How to make Colts vs. Steelers picks
The model has broken down Monday Night Football’s Steelers vs. Colts matchup from all angles. It is leaning Over the total, with the model projecting 41 combined points. It also says one side of the spread hits almost 60% of the time. See who it is at SportsLine.
So who wins Steelers vs. Colts on Monday Night Football And which side of the spread hits almost 60% of the time? Visit SportsLine now to find out which side of the Steelers vs. Colts spread you should be all over, all from the model on a 155-109 roll on its top-rated NFL picks, and find out.

