Brandon Staley and the Los Angeles Chargers will face a divisional foe on Monday Night Football. The Chargers are on a two-game winning streak with a 3-2 overall record, but Los Angeles will see a stout defense when the Denver Broncos arrive in Week 6. Denver is 2-3 overall and 0-2 on the road this season. The Broncos are on a two-game losing streak, and Denver and Los Angeles split two contests last season.
Kickoff is at 8:15 p.m. ET in Los Angeles. Caesars Sportsbook lists Los Angeles as the 4.5-point home favorite, while the over/under, or total number of points Vegas thinks will be scored, is 45.5 in the latest Broncos vs. Chargers odds. Before locking in any Chargers vs. Broncos picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Broncos vs. Chargers and just locked in its picks and MNF predictions. You can visit SportsLine now to see the model’s picks. Here are the NFL odds and betting lines for Chargers vs. Broncos:
- Broncos vs. Chargers spread: Chargers -4.5
- Broncos vs. Chargers over/under: 45.5 points
- Broncos vs. Chargers money line: Chargers -220, Broncos +180
- DEN: Broncos are 1-4 against the spread this season
- LAC: Chargers are 4-1 against the spread this season
- Broncos vs. Chargers picks: See picks at SportsLine
Featured Game | Los Angeles Chargers vs. Denver Broncos
Why the Broncos can cover
Bradley Chubb leads an impressive Denver defense. The former top-five pick has a Pro Bowl selection on his resume and is in the top five of the NFL with 5.5 sacks in five games this season. He also has eight quarterback hits, putting pressure on the opposition, and the Chargers are in the bottom 10 of the NFL in yards per carry (3.6) and rushing yards per game. Los Angeles is also below-average on third down (39.1%) and in the red zone (52.1%).
The Broncos are in the top five in points allowed (16.0 per game), points allowed per drive (1.30), total yards allowed (289.0 per game), yards allowed per drive (25.5), passing yards allowed (176.6 per game), yards per pass attempt allowed (6.1), passing touchdowns allowed (three), and red zone efficiency allowed (27.3%). Denver is also in the top eight in pressure rate, first downs allowed, sack rate, and third down efficiency allowed. See which team to pick here.
Why the Chargers can cover
Los Angeles is excellent on offense, ranking in the top five in passing yards and total yards, with top-10 marks in scoring. The Chargers are also in a favorable spot on defense against Denver in Week 6. Los Angeles has six interceptions already this season and is yielding only 7.0 yards per pass attempt. The Chargers also have an effective pass rush with 11 sacks in five games, and Khalil Mack is off to an excellent start. Mack, a six-time Pro Bowl selection, has 81.5 career sacks and owns five sacks and six tackles for loss already in 2022.
Los Angeles is also facing a vulnerable Denver offense that is averaging only 15.0 points per game. That is the second-worst total in the NFL, and the Broncos are scoring on only 29.3% of possessions this season. Denver is No. 27 in first downs created, and Russell Wilson has been sacked 16 times in five games. The Broncos are below-average in passing yards and rushing yards, with the third-worst third down conversion rate (30.6%) and the league’s worst red zone efficiency mark at 21%. See which team to pick here.
How to make Broncos vs. Chargers picks
SportsLine’s model is leaning Over on the point total. In fact, it’s calling for 47 combined points. It also says one of the spread has all the value. You can only get the model’s MNF picks at SportsLine.
So who wins Chargers vs. Broncos on Monday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Chargers vs. Broncos spread to jump on, all from the advanced model that is up nearly $7,000 on its NFL picks, and find out.

